Multiple desmoplastic melanomas in Birt-Hogg-Dubé syndrome and a proposed signaling link between folliculin, the mTOR pathway, and melanoma susceptibility.

methotrexate, psoralen–UV-A) or whose disease failed to respond to such treatments. Nail psoriasis is seen in 50% of patients with psoriasis and in about 80% of patients with psoriatic arthritis. The management of nail psoriasis can be very challenging. The choice of treatment depends on the clinical presentation andspecificpatient factors. Systemic treatment is indicated when nail psoriasis is severe or extensive skin lesions and psoriatic arthritis coexist or when topical treatment fails. In our patient, ustekinumab proved rapidly efficacious in the treatment of nail disease, improving his nail abnormality-induced psychological stress. Our findings are in agreement with existing limited data regarding the effectiveness of ustekinumab in nail psoriasis.